Why Tramadol. Why its manufacturer developed it?

It is possible to say that Germany was the place where Tramadol was designed because it was a Germany pharmaceutical company the one that launched it for the first time. Grünenthal GmbH was founded in the 1940’s and they have never stopped to invest in investigation and development to find better drugs to help patients. Throughout their history, the whole company has focused their energy to develop better in analgesics, gynecological formulations and new substances delivery systems.

Why Tramadol? Because Grünenthal has been always committed to patients’ well-being and they fulfill their ambition by introducing Tramal® in 1977. This medication is a centrally acting analgesic for treating moderate to severe pain. Although part of its mode of action remains unknown, from preclinical trials at least two complementary mechanisms appear applicable: binding of parent and M1 metabolite to m-opioid receptors.

Why Tramadol? Grünenthal GmbH is Tramadol designer and they are a guarantee of reliability and good manufacturing. They are also experts in pain management. Grünenthal discovered that this active ingredient could provide patients and doctors with a wide range of therapy options. Regarding pharmaceutical forms, Grünenthal offers a range of different products that enable doctors to find the best option for their patients: solution for injection, capsules, soluble tablets, oral drops and suppositories.

Why Tramadol? Because Grünenthal established that Tramadol has a weak respiratory depressant effect when compared with morphine.

Why Tramadol? Because it changes the way human body feels pain.

Why Tramadol? Because it provides adequate pain relief in patients with different types of pain.

Why Tramadol? Because many clinical trials have showed that is more effective than other analgesics in some particulars kinds of pain.

Why Tramadol? Because many other trials have demonstrated the acceptable safety profile of a well administered dosage schedule of Tramadol in patients with low back pain and hip or knee osteoarthritis.

Is the information described below enough to make you feel more confident if you are prescribed Tramadol? If not, go on reading and you will find the answer for all your questions.

How pain was relieved before 1970’s? Lots of different substances were utilized to alleviate pain. In the past, most of these preparations were obtained from plants. They were powerful but there were also danger because of the risk of overdose. One of the most popular substances at that time was opium, derived from the poppy flower. Regarding surgeries, most of them were performed without anesthesia and patients had to bear pain like mythological heroes. The medical literature also reports the use of a strange anesthetic device: the soporific sponge. It is said that its use was ineffective.

Friedrich Wilhelm Sertürner discovered a powerful analgesic agent from basic opium in 19th century. He called the chemical “morphine” in honor of Morpheus, the Greek God of dreams. In the same century, the famous pill called Aspirin that contained Acetylsalicylic acid was launched by Bayer and since then it has been used to relieve mild and moderate pain.

In 1960’s, a collaboration between two psychologists developed “the gate control theory”. This theory explains that a gating mechanism within the spinal cord that was closed in response to normal stimulation was opened when pain fibers transmitted an important volume of sensory signals. This hypothesis was an enormous help to discover more effective analgesics because these physiologists affirmed that the gate could be closed again to avoid pain.

What happened between Aspirin and Tramadol? Many other analgesics were introduced on the pharmaceutical market but several years were needed to develop an effective painkiller to treat moderate to severe pain.

Why Tramadol? Because it is not a “miracle” drug but it works. In addition, more clinical trials are being performed on many volunteers to establish if Tramadol has other therapeutic uses, such as the improvement of premature ejaculation.

Therefore, the question: Why Tramadol? can have many answers but most of them lead to Tramadol efficacy. This key is the one that opens the door of recovery for those patients who need Tramadol help to manage their pain. Why Tramadol? Because it may be the best choice!